NIOD Modulating Glucosides (MG) Review

(Not sponsored. No affiliate links.)

What is it?

The latest member of Deciem’s NIOD core regimen family released in May 2018. Emulsion of pH 4.50-5.50 made to heal, calm and soothe red, inflamed, irritated skin. Not just as a short-term remedy, but rather a product targeting underlying cause of skin inflammation.

NIOD Modulating Glucosides Review

This is what Deciem (of course you know of Canadian Deciem, we had their The Ordinary line reviewed here) says about this product:

Modulating Glucosides is a concentrated emulsion to target signs of skin sensitivity, of discomfort and of irritation. This serum reduces the looks of redness, of itching and of irritation, while helping to target stinging sensations. The formula respects skin integrity and supports hydration, skin barrier and general dermal repair. /NIOD/

Ok, my rosacea called for it.

This emulsion comes in typical NIOD design 30 ml / 1 fl.oz. glass bottle with the pipette. It is of light beige yellowish colour and has pharmacy herbal scent to it. Texture is very pleasant light viscous emulsion with excellent spreading ability.


How to use it?

NIOD Modulating Glucosides Review

Apply a few drops to face AM and PM. If used as part of a NIOD regimen, apply after CAIS but before MMHC. /NIOD/

I do combine it with other lines of skin care products, but I tend to apply it as close to skin as possible. This is rather a treatment product that is always better to apply on clean(sed) skin to get the best of it.


NIOD Modulating Glucosides Ingredients

Aqua (Water), Squalane, Isodecyl Neopentanoate, Glycerin, Caprylic/Capric Triglyceride, Pentylene Glycol, Propanediol, Hexyldecanol, Bisabolol, Butylene Glycol, Epigallocatechin Gallatyl Glucoside, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Hydroxymethoxyphenyl Decanone, 4-t-Butylcyclohexanol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic Acid, Palmitoyl tripeptide-8, Superoxide Dismutase, Sodium PCA, PCA, Arginine, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Aspartic Acid, Sodium Lactate, Mirabilis Jalapa Callus Extract, Tasmannia Lanceolata Fruit/Leaf Extract, Zingiber Officinale (Ginger) Root Extract, Curculigo Orchioides Root Extract, Isochrysis Galbana Extract, Brassica Campestris (Rapeseed) Sterols, Stearic Acid, Dextran, Isoceteth-20, Polyacrylate Crosspolymer-6, Xanthan gum, Tocopherol, Propyl Gallate, Tromethamine, Dehydroacetic Acid, 1,2-Hexanediol, Benzyl Alcohol, Phenoxyethanol, Caprylyl Glycol

More on this formulation and ingredients please find on official NIOD MG website.

Rosacea safe?

Generally yes, but still do a patch test. There are so many ingredients listed here, although none of them raise red flag, there is a possibility something can go wrong.

Who is it for?

All skin types, red, irritated skin, sensitized skin, sensitive skin

NIOD Modulating Glucosides Review

Does it work?


Truth be told, I don’t know. It very much makes me remember of NIOD Superoxide Dismutase Saccharide Mist of the first generation that made my skin inflammation reignited. While everyone raved about SDSM, I was trying to decipher what went wrong with my skin.

Superoxide Dismutase (SOD) is a powerful natural antioxidant present in our cells and its function is to fight free radicals to prevent the cell damage. Yeast derived SOD is present in vast majority of NIOD products and it actually is a fundament of NIOD goal – to prevent cell damage and to work the skin care within the cellular processes. And that is simply ingenious. Except one thing. My skin didn’t understand SDSM language.

This product is slightly different. Although both SDSM and MG are made to calm and soothe skin, this emulsion is more engaged and works more sophisticated way to save skin from various kinds of discomfort. It targets skin problems with big guns like Bio-Active Glucosides, Multi-Molecular-Lipid Complex, Neuro-Cosmetic Peptide, Naringenin Chalcone, Yeast-Derived Superoxide Dismutase, pH-Balancing Golden-Eye Grass Complex, Activated Cells from the Marvel of Peru, Tasmanian Pepperberry and Purified Levomenol. From itching and burning sensation to treating persistent redness caused by chemical or physical or pathological stressors. My rosacea ticks all the boxes. But, something is missing…

Emulsion per se is very pleasant on skin. Very easy to spread and with nice moisturizing effect to it. Velvety texture is very satisfying and makes the application almost a meditative experience. The scent of remedy (you know that chemical, pharmacy, healing, herbal) creates the “everything is gonna be alright” feeling.

I am about to finish this bottle and I still cannot decide whether it did something good or bad to my skin. I am simply infatuated with the science behind this product and my hopes went high to the moon. In this period of using MG I had good and bad skin days, and all MG left me with is the question was it a cause or a consequence.

Thumbs up?

Thumbs up for great science behind it. Great product, my bad my skin doesn’t understand it. If it does eventually, I will edit this text.



  1. Oh it’s nice to find out I’m not the only one! My skin isn’t too keen on this, not enough to make it mad but I’m not seeing anything positive either.


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